VIROLOGIST: STOP COVID VACCINES NOW!
COVID-19 Shots Will Result in Deadlier Strains
Re-Posted by Luis B. Vega
for PostScripts News (PSN) | www.PostScripts.org
‘It is frightful that People who are so ignorant should have so much influence.’ -George Orwell
The purpose of this posting is to present the work of Dr. Geert Vanden Bossche, PhD, DVM. He is sounding the alarm about the dangers of this new experimental ‘vaccine’. His published Scientific Paper and presentation given at the Vaccine Summit in the USA will be presented in its entirety. Dr. Bossche is a GAVI/Bill Gates paid/hired Research Expert, a Virologist is emphatically calling for the immediate halt to the worldwide mass-vaccination of millions that is being undertaken due to the COVID-19 outbreak.
He claims that the COVID-19 shots are the wrong application and will render a Person’s Natural Immunity eventually non-responsive. This will be due to an Auto Immune condition that will certainly lead to death, eventually. The Doctor will provide evidence and proof from his years of experience to show that the COVID-19 shots will allow stronger, deadlier, versions of the disease to emerge, and will kill People faster.
He is pleading to his fellow Scientific Community to stop all COVID-19 vaccinations immediately. He has sent his finding and Letter of Appeal to the World Health Organization WHO and the U.S. Centers for Disease Control CDC because the COVID-19 shots will destroy a Person’s ‘Innate Ability’ to deal with future viruses, and cause more deadly strains to develop faster, killing the people who got the vaccine.
According to Dr. Vanden Bosshe says: ‘Vaccine deployment in the ongoing mass immunization campaigns is highly likely to further enhance (adaptive) immune escape as none of the current vaccines will prevent replication/ transmission of viral variants. The more we use these vaccines for immunizing people in the midst of a pandemic, the more infectious the virus will become. With increasing infectiousness comes an increased likelihood of viral resistance to the vaccines.
It's not exactly rocket science, it’s a basic principle taught in a student’s first vaccinology class: One shouldn’t use a prophylactic vaccine in populations exposed to high infectious pressure (which is now certainly the case as multiple highly infectious variants are currently circulating in many parts of the world). To fully escape selective immune pressure exerted by vaccinal antibodies, Covid-19, a highly mutable virus, only needs to add another few mutations in its receptor-binding domain …
The paper is rather ‘scientific’ and presented thus before a scientific audience that has prior knowledge of terms and statements. However, it should be presented on its merits alone and for documentation if at least. Even though most of the terminology is highly specialized, one can get enough of the message and concerns. There is a conclusion and will summaries the finding that those with a common knowledge of a biology course could grasp.
It is very critical and a bombshell of a release as ‘one of their own’ has come forth to ‘blow the whistle’ at the expense of his career and reputation. He is genuinely concerned for the sake of Humanity as he states and for the future of his one one’s children. This is to be applauded and why not more like him are denouncing a sure mass Genocide to result in the subsequent time coming. In his summary, he like most other Doctors that have come forth identify the same issue. Eventual catastrophic Organ Failure, and Auto Immune Syndrome or ‘AIDS. The problem is that by using an mRNA type of shot during a pandemic, Humanity is only killing-off a small portion of only the COVID-19 strain.
A significant portion of the virus will escape the human Immune System and will adapt to survive. The adaptations will be much more infectious and much harder to kill. But because the mRNA shots are only instructing the human Immune System to look for only a specific version of the COVID-19 strands, one’s Immune Systems will not respond to the variations. That will result in far worse death rates in people who got the vaccine. Following is the unedited and unaltered Scientific Paper and presentation other than it has been reformatted. Dr. Vanden Bosche's warning to the world is to stop the mass inoculation of Humanity with this COVID-19 that according to him is the wrong application and will lead to COVID catastrophe.
Why should current Covid-19 vaccines not be used for mass vaccination during a pandemic?
Vaccines Summit Ohio 2021
March 1-3, 2021
G. Vanden Bossche, DVM, PhD
Independent Vaccine Research Consultant
NONCONFIDENTIAL; DO COPY; DO DISTRIBUTE
1-Prophylactic vaccines are for use in…a conventional prophylactic setting, NOT in a pandemic setting
Prophylactic vaccines should be administered before infectious exposure to:
-Ensure full-fledged protection
-Prevent exacerbation of disease (cfr. Ebola – ring vaccination)
-Prevent immune escape and hence, enhanced infectiousness or even, resistance to the vaccine
General Rule: Virus replication on background of suboptimal immune response enables immune escape of highly mutable viruses.
2-Current Covid-19 vaccine technologies
All of them are targeted at inducing specific Abs to S-protein (S1- RBD), so none of them prevents viral replication if Abs are too low in concentration or affinity
They cannot control replication of more infectious CoV variants and may even drive immune escape (e.g., when fully vaccinated subjects are exposed to viral variants)
-Yes, at the level of the individual.
-Absolutely not, for human populations exposed to Covid-19 pandemic
-Yes, at the level of the individual.
-Absolutely not, for human populations exposed to Covid-19 pandemic.
3-Gaps in our understanding of the natural course of viral pandemics
WEAK INNATE IMMUNITY
ADAPTIVE IMMUNITY ------------> DISEASE
WANING Ab TITERS
-Why does natural (i.e;, w/o human intervention) viral pandemic comprise 3 waves?
-Why does 2nd wave typically hit younger people?
-Why / how does the virus re-emerge to become seasonal?
Ag: Antigen; Abs: Antibodies
*NACs: Natural asymptomatic carriers ; refers to subjects who do not develop any clinical symptoms at all or develop at most mild disease (involving upper respiratory- airways only), after PRIMARY CoV infection.
4. The current COVID-19 pandemic is often compared to the 1918 H1N1 influenza pandemic
For example, the 1889 -92 influenza outbreak had three distinct waves, which differed in their virulence. The second wave was much more severe, particularly in younger adults.
Three waves of death: weekly combined influenza and pneumonia mortality, United Kingdom, 1918–1919. The waves were broadly the same globally during the pandemic. Taubenberger JK, Morens DM. 1918 Influenza: the Mother of All Pandemics. Emerg Infect Dis. 2006;12(1):15-22., CC BY
5. Abrogation of viral infection in NACs (after short-lived virus replication) is mediated by innate immunity
6. Abrogation of viral infection at an early stage of infection is the virus’ secret weapon to ensure its own perpetuation
8 vs 4 = 2:1
8-2 vs 4-2= 6 vs 2= 3:1
IV: Immune escape variant
OCS: Original circulating strain
NIV: New immune escape variant
Thin arrows: Low affinity
Thick arrows: High affinity
7. Increasing CoV infection rates promote enhancement of innate immune suppression in NACs (à more susceptible to disease)
Susceptibility rate in NACs suffices to compensate for long enough….
until Ag-spec. Ab titers in nonNACs drop à virus can replenish replication capacity
8. Containment measures and vaccination of NACs jeopardize capacity for viral replication
Viral Infectiousness in NACs suffices to compensate for long enough…until Ag-spec.
Ab titers in nonNACs drop.
9. But what if these Ab titers don’t drop??
10. Increasing infection/ seropositivity rates in NACs and nonNACs promote immune escape
Enhanced infection rates lead to increased rates of transient seropositivity in NACs; seropositivity suppresses innate immunity because Ag-specific Abs outcompete NABs for binding to CoV and prevent training of innate immune system
1.Selective (innate) immune escape in NACs <-----
3.Selective (adapt.) immune escape in nonNACs ----->
11. Strange observations during ongoing Covid-19 pandemic…
= Selective (S/ RBD) protein-directed) immune escape
S: Spike protein
RBD: Receptor-binding domain
12. Mass containment measures and mass vaccination in NACs accelerates INNATE immune escape whereas mass vaccination of nonNACs accelerates INNATE and ADAPTIVE immune escape
If needed, both NACs and nonNACs can serve as a potential source of immune escape upon human intervention in natural CoV pandemic.
Immediate cancellation of all ongoing Covid-19 mass vaccination campaigns should now become THE most acute health emergency of international concern.
Executive summary (see also slide appended on p.6 below)
The manuscript, which is in now in the process of being finalized, should shed some light on how the virus and especially its interaction with the host immune system determines the natural course (i.e., without human intervention) of a Coronavirus (CoV) pandemic. The interplay between host immune defense and viral immune escape determines the course of a natural CoV pandemic (including a natural Covid-19 pandemic).
In the clinic, viral immune escape is known to occur when the neutralizing capacity of serum antibodies (Abs) does not suffice to fully eliminate highly mutable viruses (e.g., CoV) for lack of their concentration or affinity. In a CoV pandemic setting, seroconversion occurs against a background of high infectious pressure and is, therefore, prone to promote viral immune escape.
The first wave of disease1 (and mortality) primarily affects elderly people (or otherwise immunocompromised subjects). Selective (i.e., adaptive) immune escape is expected to cause this wave to transition into a more severe, second wave in younger age groups. Subsequently, non-selective (i.e., innate) as well as selective immune escape operated by increasingly infectious viral variants will trigger a third wave. The latter would primarily affect subjects who recovered from disease they contracted during the first wave as their seroneutralising Abs do no longer properly match the new circulating viral variants. This third wave of disease (and mortality) would come to an end when those who recovered from the disease will have mounted new functional Abs against these immune escape variants.
As seroconversion in this population will now occur much faster (due to recall of cross-reactive T helper memory cells) and as the majority of the young and middle-aged population will either be seronegative or have seroconverted already by the time the third wave starts to expand, chances are slim for the virus to escape the host’s Ab response. Asymptomatic2, seronegative individuals (i.e., the vast majority of young and middle-aged people) may spread virus upon (re-)infection and hence, constitute a relevant source of viral transmission. However, CoV infection in these asymptomatic carriers is abrogated after a short period of viral shedding. Viral clearance in these subjects is likely to occur through activation of NK cells. The latter are capable of recognizing CoV-associated, antigen (Ag)-nonspecific patterns on the surface of CoV-infected epithelial target cells. As killing by NK cells is, therefore, not Ag-specific and as seroconversion in asymptomatically infected subjects is only short-lived, viral immune escape does not normally occur. Consequently, new, more infectious, variants are unlikely to emerge from this population as long as viral infectiousness does not dramatically increase.
At the point of ‘no immune escape’, the pandemic will be under control and merge into an endemic infection. However, as long as the point of ‘no immune escape’ isn’t reached, any additional immune selection pressure, for example as a result of suboptimal concentration or affinity of Ag-specific (e.g., spike protein-specific) Abs, will allow the virus to rapidly unfold more infectious, immune escape variants. Additional immune selection pressure, especially when exerted during the second wave of a CoV pandemic, is likely to precipitate and amplify viral immune escape. This might even cause the second and third wave to merge into a single huge wave of mortality and disease that affects all layers of the population (possibly, with the exception of small children).
Especially mass vaccination campaigns, particularly when conducted in the midst of a pandemic, are prone to exerting enormous immune pressure on circulating virus strains. This is because the vaccine is used in an increasingly infectious context (as escape variants are more infectious). Mass vaccination campaigns will accelerate the emergence of even more infectious immune escape variants. This because the number of vaccine recipients who seroconvert within a given time period will dramatically increase3. In addition, Ag-specific, high affinity Abs induced by any of the current vaccines will outcompete natural, broadly protective mucosal IgM antibodies as the latter only bind with low affinity to the receptor-binding domain of CoV (RBD). This will particularly affect natural resistance of younger age groups which - thanks to a well-trained innate immune system- resisted disease during the first wave. The new circulating CoV variants may now even be able to escape the host’s CoV variant-nonspecific line of immune defense at the mucosal portal of entry. These age groups may, therefore, become more susceptible to symptomatic infection and shedding caused by more infectious variants.
But mass vaccination campaigns will also have severe consequences for those who got vaccinated first (mostly the elderly or people with underlying disease or those who are otherwise immunocompromised). In the highly likely event that mass vaccination will soon result in antiviral resistance (see below), these people will have no single bit of immunity left to rely upon. In contrast to the infectious circulating virus, current vaccines do either not contain any critical killer cell motif or fail to activate dedicated killer cells. It goes, therefore, without saying that vaccine-induced immune responses will inevitably result in a dramatic enhancement of morbidity and mortality rates in all of the human population (except for small children?).
Further to all of the above, low exposure to circulating CoV strains (e.g., due to stringent containment measures) will increasingly weaken innate mucosal immunity for lack of training. Again, this is particularly relevant for those who - thanks to their sufficient and adequate innate immune defense – got away with asymptomatic infection during the first wave. Stringent and widespread infection prevention measures are now increasingly compromising their innate immunity and rendering them more susceptible to symptomatic infection. Especially the younger age groups may, therefore, end up with relatively higher morbidity and mortality rates, even regardless of the emergence of more infectious viral variants. This is to say that broadly implemented infection prevention measures will only amplify the already detrimental consequences of ongoing mass vaccination campaigns. It is reasonable to assume that the combination of non-selective and selective immune escape will cause morbidity and mortality rates in younger age groups to explode (see figure attached on p.6 below).
The more Covid-19 vaccination campaigns in the young and middle-age groups will be delayed (i.e., relative to their initiation in the elderly), the more they will enhance morbidity and mortality rates in this group: By the time mass vaccination campaigns are about to start in the young and middle-aged groups, a substantial number of these people will already have been infected with Covid-19. Enhanced rates of infection by highly infectiousness viral variants have now significantly increased the likelihood for them to become re-infected while being in the process of seroconverting. So, by the time vaccinations will be initiated, viral immune escape in this group may already be fueling a vicious circle of enhanced viral infectiousness resulting in more seroconversion and hence, more immune escape.
Mass vaccination campaigns in this group will only dramatically deteriorate the situation as they will lead to a fast and massive increase in the number of asymptomatic subjects that are in the process of seroconverting against a highly infectious background and, therefore, are prone to promoting viral immune escape. As there is naturally no reason for them to isolate, there will be plenty of opportunity for the highly infectious circulating strains to replicate in the presence of suboptimal Ab titers and, therefore, to escape the host’s immune control.
Hence, the more vaccination campaigns in this group get delayed, the more selection of even more infectious viral variants will be expedited. The ensuing exponential increase in viral immune escape rates will ultimately enable viral variants to even break through vaccine-mediated protection in the vaccinated elderly. As their Abs increasingly mismatch the ever more infectious emerging variants, they will no longer manage to control viral replication and shedding and rapidly allow for massive viral immune escape. Because seroprotective Abs primarily confer protection through targeting Covid-19’s RBD, the virus will now increasingly select mutations in this particular part of the spike protein as those most readily enable the virus to escape vaccine-induced Abs. This will inevitably precipitate resistance to the vaccine. As a result of mass vaccination, people who got the vaccine first will suddenly no longer be protected and, despite vaccination, fall prey to a wave of catastrophic morbidity and mortality.
There can, therefore, be no doubt that current vaccination strategies are rendering the impact of mass vaccination campaigns even more catastrophic and only adding to the magnitude of a pending global health disaster. However, mass vaccination also harms individual health as vaccine-induced variant-specific Abs will outcompete natural variant-nonspecific mucosal Abs for binding to CoV variants and thereby deprive individuals from their broadly protective natural (life)line of immune defense.
As large-scale vaccination campaigns combined with the sustained implementation of several containment measures will only expedite the occurrence of viral escape mutations, the illusory hope that current Covid-19 vaccines could generate herd immunity should once and for all be thrown overboard. Along the same line of reasoning, it is not unthinkable that Covid-19 will, once again, cross species barriers. One can definitely not rule out that with growing immune-mediated selection of virus variants, Covid-19 is ultimately going to be able to jump to other animal species, especially industrial livestock (e.g., intensive pig and poultry farms with high stocking density) as i) these species are already known to host several different Coronaviruses and ii) variability/ mutations in the very same spike protein, and particularly in the RBD, are known to be responsible for shifts in host tropism/ susceptibility. Similar to the situation with influenza virus, these animal species could then constitute a reservoir for SARS-COVID-2 virus. Depending on the prevalence of circulating animal CoVs in those farms (and hence, the level of trained immunity), those animals could now serve as asymptomatic carriers, thereby constituting a serious threat to humans.
The combination of mass vaccination and infection prevention measures is a recipe for a global health disaster. Following the science, one has to conclude that all age groups (possibly with the exception of small children) will be heavily affected and subject to rates of morbidity and mortality that raise much faster and much higher than those expected to occur during the natural course of a CoV pandemic. This will particularly apply if the sequence of mass vaccinations following the first infectious wave parallels that of natural infection (i.e., immunocompromised people and elderly first, followed by the younger age groups).
No one, for that matter, should be granted a right to implement large-scale pharmaceutic and non-pharmaceutic immune interventions, especially not during a viral pandemic, and certainly not without an in-depth understanding of the immune pathogenesis of a viral pandemic. When one follows the science, and nothing but the science, it becomes extremely difficult to not label ongoing mass vaccination campaigns as a crime, not only to public health but also to individual health. To substantiate the reasoning above, the manuscript will first explain how components of the innate immune system can protect against Covid-19 and render infections asymptomatic.
It will then go on to explain in more detail why and how, in an immunologically Covid-19-naïve population, selective (i.e., adaptive) immune escape shifts the first wave of disease and death from the elderly (and immunocompromised) subjects to those who at the outset of the pandemic got away with asymptomatic infection (i.e., the younger and middle-aged population segment). Similarly, it will be explained how accelerated viral immune escape in the asymptomatically infected population finally shifts back the burst of morbidity and mortality to the elderly, and how the population eventually controls the pandemic by controlling viral immune escape.
This will already illustrate the critical importance of desiccating the changing contribution of innate and adaptive immunity to the population’s overall immune defense against a viral pandemic. Understanding these dynamics helps to comprehend the sophisticated course of a natural CoV pandemic, how it eventually merges into an endemic infection and why human intervention has a highly detrimental impact on the refined interplay between the virus and its host. In regard of the latter, the devastating global health impact of ongoing mass vaccination campaigns and accompanying stringent and widespread containment measures will be explained in more detail as the global and individual health consequences could simply be unbearable for many years to come.
After the introductory section on innate immune defense mechanisms relevant to Covid-19, other relevant topics will be addressed in form of questions and answers. Last, a section will be dedicated to the scientific rationale for using NK cell-based vaccines that could provide sterilizing immunity and hence, wipe out Covid-19 and related variants all together.
The natural course of a CoV pandemic is controlled by the population’s innate and adaptive immunity and dramatically aggravated by antibody-based vaccines when used in mass vaccination campaigns conducted in the course of the pandemic and flanked by stringent containment measures
Natural asymptomatic carrier : for the purpose of this manuscript, NAC is defined as a subject disposing upon a level of innate immunity high enough to resist disease.
For the purpose of this manuscript, nonNAC is defined as a subject who is not endowed with a level of innate immunity high enough to be able to resist disease when exposed to infectious virus during the first wave.
1 For the purpose of the manuscript, ‘disease’ refers to severe Covid-19 disease with involvement of lower respiratory airways.
2 For the purpose of the manuscript, ‘asymptomatic’ infection refers to CoV infection which does not cause clinically relevant symptoms or only causes a mild level of disease (i.e., only involving upper respiratory airways).
3 Alike naturally infected subjects, vaccine recipients need time to mount a full-fledged Ag-specific Ab response.
Author: G. Vanden Bossche, DVM, PhD; 26 February 2021
Formatted by Luis B. Vega
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This is PostScripts News Article #470.
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